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Hydrea, also available in the generic alternative Hydroxyurea generic, is an antineoplastic drug that is used in the treatment of myeloproliferative disorders such as polycythemia vera and essential thrombocythemia.  The generic alternative is not manufactured by the company that makes the brand product.  It works by reducing the production of deoxyribonucleotides by inhibiting the enzyme ribonucleotide reductase.  Hydrea can also increase the concentration of foetal haemoglobin.  Hydrea increases nitric oxide levels, which causes soluble guanylyl cyclase activation, which in turn causes a rise in cyclic GMP.  Hydrea was first synthesized in 1869, and this was an important discovery in the treatment of many bone marrow diseases.

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