Zelapar (Selegiline) is used along with carbidopa and levodopa to treat symptoms of Parkinson's disease. Zelapar prevents the breakdown of a chemical in your brain called dopamine. Low levels of this chemical are associated with Parkinson's disease.  Zelapar (Selegiline) works to increase and extend the effects of levodopa, and may help to slow the progress of Parkinson’s disease.  

Zelapar should not be taken with tricyclic antidepressants or non-selective MAO inhibitors or selective MAO-B inhibitors.  The interaction between these drugs could be life threatening.  You should not use alcohol or consume foods that contain high amounts of tyramine, as this might alter the effects of the medication.  You should inform your doctor if you are pregnant or breastfeeding before you take Zelapar (Selegiline), as this medication may be harmful to the baby.

Advise  your doctor if you have kidney disease, liver disease, heart disease, high or low blood pressure, or a seizure disorder before you begin using  Zelapar (Selegiline).  If you have any of these conditions, you may need a dose adjustment or special tests to safely take Zelapar.

There are a number of medications that may interact with Zelapar (Selegiline).  It is important to provide your physician with a complete list of all medications that you are taking or have recently taken. Antidepressants, nafcillin, rifampin, diet pills, carbamazephine, and Phenobarbital are just some of the medications that may react with Zelapar.  There are many other medicines that can cause serious medical problems if you take them together with Zelapar. Do not take Zelapar before telling your doctor about all other prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors.

You should stop taking Zelapar and call your doctor at once if you experience any of these serious side effects: sudden and severe headache; hallucinations; feeling restless, agitated or irritable; problems with speech or balance; sudden numbness or weakness.

You should continue using Zelapar (Selegiline) and talk with your doctor if you have any of these less serious side effects: dizziness, weakness; runny or stuffy nose; back pain; sleep problems; constipation; mouth sores or pain when swallowing.

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