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Vaniqa (Eflornithine) was originally developed as a cancer treatment, but was found to be far more effective in inhibiting the enzyme ornithine decarboxylase (ODC), which is responsible for catalyzing ornithine to putrescine. Putrescine is crucial to the growth and proliferation of cells in the hair follicle. This means that when Vaniqa (Eflornithine) is applied topically as a cream, it can be very effective in inhibiting hair growth. Since ODC also plays a role in the multiplication of trypanosomes, the kind of protozoa that are responsible for causing African sleeping sickness, Eflornithine is also be an effective treatment for this disease when injected into the bloodstream.

Vaniqa (Eflornithine) is, however, the cream form of the drug, and its sole purpose and use is to inhibit hair growth in women afflicted with facial hirsutism. This condition is characterized by an excessive hairiness in areas where hair does not normally occur, and afflicts five to fifteen percent of the female population. Vaniqa (Eflornithine) is very effective in inhibiting hair growth, particularly in the facial region. Many patients opt to have this unwanted facial hair removed and then keep it from growing back with the regular topical application of Vaniqa (Eflornithine). This has proven to be a highly effective treatment in most women with this condition.

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