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Generic Name: Maprotiline hydrochloride

Maprotiline (maprotiline hydrochloride) is a tetracyclic antidepressant used in the treatment of depression.  The drug is also used to treat the depressive phase of bipolar disorder and to relieve symptoms of anxiety and insomnia.  Maprotiline (maprotiline hydrochloride) strongly affects the neurotransmitter norepinephrine, inhibiting its reuptake by certain nerve cells, and thus increasing its availability in the brain.  To a lesser extent, Maprotiline (maprotiline hydrochloride) also inhibits the reuptake of the neurotransmitters serotonin and dopamine.  By maintaining high levels of these neurotransmitters, especially norepinephrine, in the brain, Maprotiline improves mood and relieves symptoms of depression.  It may take up to four weeks for the patient to notice the anti-depressive effects of Maprotiline.  In the first few weeks of treatment, Maprotiline has a pronounced sedating effect and is therefore helpful in treating depressed individuals exhibiting symptoms of agitation, anxiety, and thoughts of suicide.  Maprotiline has no discernable effect on the mood of an individual who is not clinically depressed. 

Maprotiline (maprotiline hydrochloride) is contraindicated as a treatment for depression in individuals who have previously exhibited hypersensitivity or an allergic reaction to maprotiline hydrochloride or to another antidepressant in the tricyclic or tetracyclic classes.  In addition, Maprotiline should not be prescribed to individuals with hypertrophic prostate glands or closed-angle glaucoma.  Special care should be taken when prescribing Maprotiline to patients with epilepsy, heart disease, or serious impairment of liver or kidney function.  Some studies suggest that maprotiline and other antidepressants may increase the incidence of suicidal thoughts in adolescents and young adults.  Common side effects of Maprotiline include dizziness, drowsiness, dry mouth, weight gain, low blood pressure, tachycardia and arrhythmia, rashes, and photosensitivity.  More serious, but less common, side effects include periods of mania, seizures, priapism, leucopenia, and liver damage.

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