Orthovisc is a sterile, non-pyrogenic solution of sodium hyaluronate for intra-articular injection. Sodium hyaluronate is a high molecular weight polysaccharide composed of sodium glucuronate and N-acetylglucosamine. It is distributed throughout the tissues of the body and is present in high concentrations in such tissues as vitreous humor, synovial fluid, umbilical cord and dermis. Sodium hyaluronate functions as a tissue lubricant and is thought to play an important role in modulating the interactions between adjacent tissues. It can also act as a viscoelastic support maintaining a separation between tissues. Different sodium hyaluronate preparations may have different molecular weights, but are thought to have the same chemical structure. The sodium hyaluronate in Orthovisc has an average molecular weight greater than one million daltons. Orthovisc is non-inflammatory and non-pyrogenic. Sodium hyaluronate preparations have been shown to be well tolerated in human eyes, non-antigenic and do not interfere with normal wound healing processes. The sodium hyaluronate in Orthovisc is extracted from a natural avian source.

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