Ovestin Cream (estriol) is a topical application for the treatment of vaginal dryness and vaginal itching and inflammation.  Although Ovestin Cream (estriol) can be prescribed for women of all ages who experience these symptoms, this medication is especially helpful in treating menopause-related symptoms.  Ovestin Cream contains estriol, a form of oestrogen, a hormone whose levels fall during menopause, sometimes causing vaginal dryness and irritation.  Applying Ovestin Cream (estriol) directly to the vaginal tissues supplements them with oestrogen and provides short-term relief for these symptoms.  Ovestin Cream (estriol) is also used to treat vaginal tissue before and after the performance of surgery for conditions such as vaginal prolapse.  Ovestin Cream (estriol) is inserted into the vagina using an applicator.  The best time to apply Ovestin Cream (estriol) is at night before going to bed.

Even though it is a topical application, Ovestin Cream is a form of hormone replacement therapy.  Long term hormone replacement therapy has been associated with an increased risk of endometrial cancer, breast cancer, and blood clots.  The risks associated with Ovestin Cream (estriol) are probably less than those associated with hormone replacement tablets.  However, it is important to note that the estriol in Ovestin Cream is absorbed from the vaginal tissues directly into the bloodstream.  Women using Ovestin Cream (estriol) should have regular gynecological check-ups and tell their doctor immediately if they experience abnormal vaginal bleeding or discharge.  If any of the following symptoms occur, use of Ovestin Cream should be stopped immediately and medical attention should be sought: stabbing pain, leg swelling, shortness of breath, coughing up blood, chest pain, sudden numbness, severe headache, jaundice, fainting, or blurred vision.  Ovestin Cream (estriol) may weaken the latex in condoms and diaphragms.  A back-up non-hormonal method of birth control should be used. 

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