Panokase 16 (pancrelipase) is a combination of three enzymes (proteins) – lipase, protease, and amylase.  These enzymes are normally produced by the pancreas and are important in the digestion of fats, proteins, and sugar.  Panokase 16 (pancrelipase) is used to replace these enzymes when the body does not have enough of its own due to certain medical conditions, such as cystic fibrosis, chronic inflammation of the pancreas, or blockage of the pancreatic ducts.  Panokase 16 (pancrelipase) is also used following the surgical removal of the pancreas. 

Panokase 16 (pancrelipase) contains: 16,000 USP units lipase, 60,000 USP units protease, and 60,000 USP units amylase.  It also contains the nonmedicinal ingredients: croscarmellose sodium, lactose, microcrystalline cellulose, silicon dioxide, stearic acid and talc.  You should not use Panokase 16 (pancrelipase) if you are allergic to pork proteins or any of the ingredients in Panokase 16 (pancrelipase).  You should advise your doctor if you have gout, kidney disease, a history of intestinal blockage, sudden onset of pancreatitis, or worsening of chronic pancreatic disease before taking Panokase 16 (pancrelipase).

There may be other drugs that can interact with pancrelipase. You should tell your doctor about all medications you use. This includes prescription, over the counter, vitamin, and herbal products.  Some of the more common and less serious side effects of Panokase 16 use may include:  nausea or vomiting, diarrhea or constipation, gas or bloating, rectal irritation, headache, dizziness or cough. You should consult your doctor immediately if you experience an allergic reaction or severe or unusual stomach pain. Panokase 16 (pancrelipase) should be taken exactly as prescribed by your doctor to help minimize the chance of side effects.

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