Benadryl Itch Relief Cream is an over-the-counter product that serves to temporarily relieve the itch and pain caused by such things as insect bites, sunburn, scrapes, poison ivy, oak or sumac rashes, mild burns or cuts, and mild skin irritations. Benadryl Itch Relief Cream will also dry up the weeping and oozing that can occur from a poison oak, ivy or sumac reaction.

The active ingredient in Benadryl Itch Relief Cream is an antihistamine called Diphenhydramine Hydrochloride. This medicine inhibits the activity of histamine, a naturally occurring chemical in the body that causes itchiness. Benadryl Itch Relief Cream also contains Zinc Acetate, which acts as a protectant on your skin.