MONISTAT 1 Combination Pack offers the convenience of a 1-dose treatment in a new, innovative OVULE insert that treats without the mess. An advanced bio-adhesive formula helps the treatment adhere to the walls of the vagina so there is less likelihood of leakage. MONISTAT 1 Combination Pack is the only one-dose treatment that comes with a separate tube of cream which starts to relieve external symptoms FAST. The active ingredient in MONISTAT1 Combination Pack is Miconazole Nitrate and it’s available without a prescription.