TOLL-FREE PHONE: 1-866-539-5330
TOLL-FREE FAX: 1-866-539-5331

Buy Prolixin Online

A prescription is required for this item.
Dosage Pack Size & Price Qty
Brand medication is not available at this time.
Product description written by Dr. Ami Patel, PharmD (July 10, 2020)

What is Prolixin (Fluphenazine)?

Prolixin (generic name Fluphenazine) is a medicine used to treat schizophrenia or psychotic disorders. Fluphenazine adjusts the amount of a chemical in your brain, called dopamine. By balancing the amount of dopamine in your brain, fluphenazine can organize your thoughts. Fluphenazine can also help if you imagine voices or see images that are not real. Sometimes people with schizophrenia believe things that are not true. Fluphenazine may help you think more clearly.

Conditions treated by Prolixin?

Prolixin (also known as fluphenazine) is used to treat and prevent psychotic disorders. Several medical conditions may cause psychotic disorders, including schizophrenia. A psychotic disorder happens when you have unusual feelings or thoughts. You may lose touch with reality. You might see, hear, or feel things that are not there. You may believe things that are not real, such as imagining that people are plotting against you.

What are the side effects of Fluphenazine?

Fluphenazine should not be used in older people who have lost touch with reality and also have trouble with memory loss and confusion. A serious side effect of Prolixin or fluphenazine includes the possibility of sudden, unexplained death in elderly people who have dementia-related psychosis. Do not use fluphenazine if you are elderly and have a history of seizures or brain damage.

Possible fluphenazine side effects include:

  • Having a stiff or painful neck, trouble swallowing or breathing (this occurs more commonly in young men who are using Prolixin or fluphenazine)
  • Unusual movements of your tongue, mouth, or lips
  • Feeling restless, like you need to move around
  • Trouble moving, feeling stiff, having slow movements or tremors
  • A medical problem called neuroleptic malignant syndrome (NMS) which can cause death. Call your doctor and go to the closest emergency room if you experience any of the following while taking fluphenazine:
    • High body temperature (fever)
    • Muscle stiffness
    • Feeling confused
    • Feeling sweaty
    • Changes in how you breathe
    • Changes in your heart rate
    • Changes in blood pressure
  • Body movements you cannot control (this is called tardive dyskinesia). You may notice twitching in your face, tongue, or other parts of your body. Some people start lip smacking or have uncontrolled chewing movements. These may linger after you stop Prolixin or fluphenazine.
  • Feeling sleepy or drowsy. Alcohol can make this worse, so avoid drinking alcohol (including beer, wine, and spirits) while on fluphenazine. Fluphenazine and alcohol do not mix.
  • Feeling restless, excited, or having strange dreams
  • Feeling sick to your stomach (nauseous) or losing your appetite
  • Drooling
  • Frequently peeing or trouble peeing
  • Sweating
  • Dry Mouth
  • Constipation
  • Headache
  • Blurred vision
  • Glaucoma
  • Fast heartbeat
  • Stuffy nose
  • Weight changes
  • Swelling in arms or legs
  • Too much prolactin in your blood. Women may notice that their period (menstrual cycle) stops, or they may start leaking breast milk even when they're not breastfeeding. False results may appear on a pregnancy test. Men may start noticing swollen breasts, or problems getting an erection.
  • Change in sexual desire, or inability to maintain an erection in men
  • Allergic reactions including itching, skin peeling, rash, or sun sensitivity
  • Changes in blood tests, including low white blood cells. Call your doctor immediately if you develop sore gums, a sore throat, or pain in your mouth as this may be a sign of a serious blood disorder.
  • Liver problems, including jaundice (call your doctor immediately if you notice yellow skin or yellow eyes)
  • Vomiting
  • Runny nose
  • Weight gain. Monitor your weight regularly due to changes in your metabolism leading to weight gain.

This is not a full list of all possible fluphenazine or Prolixin side effects.

If you use fluphenazine, and think you are experiencing any Prolixin or fluphenazine side effects, please call your doctor immediately.

What you should know before using Fluphenazine?

Fluphenazine should not be used in elderly people with dementia, because it may increase their risk of sudden death.

Do not use fluphenazine or Prolixin if you have had an allergic reaction to any of the following medications in the past:

  • fluphenazine
  • Prolixin
  • perphenazine
  • promethazine
  • thioridazine
  • trifluoperazine
  • chlorpromazine
  • proclorperazine

Do not use fluphenazine or Prolixin if you have liver disease, brain damage, changes in your blood tests, or severe depression. Tell your doctor if you take any other prescription or over-the-counter vitamins or supplements because some can interact with Prolixin or fluphenazine.

If you have any of the following medical conditions, tell your doctor before starting fluphenazine or Prolixin:

  • Kidney problems, or a history of kidney problems
  • Liver problems, or a history of liver problems
  • Low blood cells
  • Glaucoma
  • Breast cancer
  • Parkinson's disease
  • Seizures
  • Pheochromocytoma (an adrenal gland tumor)
  • Are pregnant or are planning to become pregnant
  • Are breastfeeding or are planning to breastfeed

Drugs Similar to Prolixin

  • Abilify (Aripiprazole)
  • Abilify Oral Dispersible Tablet - DiscMelt (Aripiprazole)
  • Abilify Oral Solution (Aripiprazole)
  • Abilify Solution for Injection (Aripiprazole)
  • Clopixol (Zuclopenthixol Dihydrochloride)
  • Clopixol Acuphase (Zuclopenthixol Acetate)
  • Clopixol Depot (Zuclopenthixol Decanoate)
  • Compazine (also called Stemetil) (Prochlorperazine)
  • Eskalith (Lithium Carbonate)
  • Fanapt (Iloperidone)
  • Fluanxol (Flupentixol)
  • Geodon (called Zeldox in Canada) (Ziprasidone)
  • Haldol (Haloperidol)
  • Invega (Paliperidone)
  • Invega Sustenna (Paliperidone Palmitate)
  • Latuda (Lurasidone)
  • Mellaril (Thioridazine)
  • Modecate Injection (Fluphenazine Decanoate)
  • Nozinan (Levomepromazine)
  • Nozinan Injection (Levomepromazine Hydrochloride)
  • Orap (Pimozide)
  • Rexulti (Brexpiprazole)
  • Risperdal (Risperidone)
  • Risperdal Consta (Risperidone)
  • Risperdal Liquid (Risperidone)
  • Risperdal M Tabs (Risperidone Oral Disintegrating)
  • Saphris (Asenapine)
  • Seroquel (Quetiapine)
  • Seroquel XR (Quetiapine Extended Release)
  • Solian (Amisulpride)
  • Solian Oral Solution (Amisulpride)
  • Sulpitil (Sulpiride)
  • Thorazine (Chlorpromazine)
  • Trifluoperazine/Chlorpromazine/Trihexyphenidyl (Trifluoperazine/Chlorpromazine/Trihexyphenidyl)
  • Trifluoperazine/Trihexyphenidyl (Trifluoperazine/Trihexyphenidyl)
  • Trilafon (known as Fentazin internationally) (Perphenazine)
  • Vraylar (Cariprazine)
  • Zyprexa (Olanzapine)
  • Zyprexa Zydis (Olanzapine)


  • How much does Fluphenazine cost?

    Fluphenazine costs can vary depending on your prescription. The dose of fluphenazine and amount of medicine you will need can change based on your medical history and age. Buy fluphenazine online to obtain the lowest price for your prescription.

  • How does Fluphenazine work?

    Fluphenazine works by changing the amount of dopamine in your brain. By balancing the amount of dopamine, fluphenazine can organize your thoughts so you can think clearly.

  • Where can I buy Fluphenazine online?

    For your convenience, you can buy fluphenazine online from a reputable online pharmacy such as, with a prescription from your doctor.

  • The information provided on the website is intended to facilitate awareness about healthcare products and medical conditions generally but it is not a substitute for professional medical attention or advice. You should always speak with a qualified healthcare practitioner before taking any prescription or non-prescription drug.