TOLL-FREE PHONE: 1-866-539-5330
TOLL-FREE FAX: 1-866-539-5331

Buy Rybelsus Online

A prescription is required for this item.
No generic alternative is available at this time.
BRAND LISTING - Rybelsus (Semaglutide)
Dosage Pack Size & Price Qty
Product description written by Dr. Eva Y. Pan, PharmD (February 16, 2021)

What is Rybelsus?

Rybelsus is an oral medication used in type 2 diabetes mellitus. The active ingredient in Rybelsus is semaglutide, which is a glucagon-like peptide-1 (GLP-1) receptor agonist. GLP1 is a hormone that helps you feel full between eating and helps your body release more insulin to break down your blood sugars. GLP1 agonists mimic the action of GLP1 hormone in the body. Patients/caregivers can buy Rybelsus online at

What is Rybelsus used for?

Rybelsus is used to improve blood sugar control in adults with type 2 diabetes mellitus, in addition to diet and exercise. Rybelsus should not be used in patients with type 1 diabetes mellitus or for the treatment of diabetic ketoacidosis (a serious complication of diabetes in which there is a buildup of acid in the body).

What are the side effects of Rybelsus?

The main side effects of Rybelsus include:

  • Abdominal pain
  • Nausea
  • Diarrhea
  • Decreased appetite
  • Vomiting
  • Constipation
  • Hypoglycemia (hypoglycemia occurs more frequently when Rybelsus is used with insulin)

Serious side effects such as pancreatitis, thyroid C-cell tumors, and diabetic retinopathy complications can occur on rare occasions. Rybelsus should not be used in patients with a personal or family history with medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2. Patients with known allergies to any components of Rybelsus should also avoid the medication.

What you should know before using Rybelsus:

Rybelsus is a tablet that comes as 3mg, 7mg, or 14mg doses to be taken once daily. Patients should be started on 3mg for about a month, and then increased to 7mg. Rybelsus reaches steady-state levels after 4 – 5 weeks of administration, hence why patients should wait about a month to see effects. The dose can be further increased to 14mg if needed, but it is not recommended to take two 7mg tablets to achieve the 14mg dose.

Rybelsus should be taken with a maximum of 4 ounces of plain water at least 30 minutes before consuming any food, beverage, or other oral medication for the day. Rybelsus tablets should be swallowed whole and not split or crushed. Rybelsus should be stored at room temperature in a dry place and kept in the original blister card until use to protect from moisture.

Patients/caregivers should be aware of potential drug interactions with Rybelsus. As mentioned, Rybelsus can cause hypoglycemia when given with insulin or insulin secretagogues. Insulin secretagogues are medications that help the pancreas release insulin; they include sulfonylureas (glimepiride, glipizide, glyburide) and meglitinides (repaglinide, nateglinide). Rybelsus can also impact the absorption of other oral medications by slowing down emptying of the stomach. Pregnant patients should only use Rybelsus if the potential benefits outweigh the potential risk to the fetus. Breastfeeding is not recommended in patients taking Rybelsus.


  • How does Rybelsus work?

    Rybelsus reduces blood glucose by stimulating insulin secretion and lowering glucagon secretion in a glucose-dependent manner. When there is more glucose in the blood, Rybelsus helps stimulate insulin release while suppressing glucagon secretion. Glucagon acts in the opposite way of insulin; it stimulates glucose production and increases blood sugar levels.

  • How much does Rybelsus cost?

    The cost of Rybelsus varies depending on the prescribed dosage. Patients/caregivers can buy Rybelsus online at a discounted price at

The information provided on the website is intended to facilitate awareness about healthcare products and medical conditions generally but it is not a substitute for professional medical attention or advice. You should always speak with a qualified healthcare practitioner before taking any prescription or non-prescription drug.