What to know before using Rydapt
The following factors should be considered before taking Rydapt (Midostaurin).
Tell your doctor if you are allergic to any of the ingredients or if you have any other known allergies. This medication contains inactive ingredients that may cause allergic reactions or side effects. If you are hypersensitive to midostaurin or its excipients, you cannot take Rydapt. Hypersensitivity reactions include: flushing, chest pain, anaphylactic shock, shortness of breath (dyspnea), and severe swelling beneath the skin (angioedema).
Speak with your pharmacist about possible reactions.
Before using this medication, tell your doctor or pharmacist your medical history, especially with regard to breathing and lung problems.
In addition, tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
Do not open or crush capsules.
Rydapt cannot be taken during pregnancy as it may harm an unborn baby. It can also pass into breastmilk. Therefore, mothers who are nursing should not take this medication. Accordingly, breastfeeding should be discontinued during treatment and should not be resumed for at least 4 months following the last dose.
If you become pregnant while taking this medication or think you may be pregnant, speak with your doctor right away. If you are able to become pregnant, your doctor should conduct a pregnancy test 7 days before you start taking Rydapt.
Effective birth control should be used during treatment and for at least 4 months following the last dose.
Men taking Rydapt who have a female partner who may become pregnant should also use effective birth control during treatment with RYDAPT and for at least 4 months following the last dose.
Rydapt may impair fertility in both males and females. This issue should be discussed with your doctor before starting the treatment.
If you vomit after taking a dose of Rydapt, do not take another dose of Rydapt. Take your next dose at your regular scheduled time.
If you miss a dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose.
Rydapt should not be co-administered with strong CYP3A4 inducers. More specifically, it should not be taken with Carbamazepine, enzalutamide, mitotane, phenytoin, rifampin, or St. John's wort, among others.
Rydapt should not be co-administered with strong CYP3A inhibitors. Do not use with grapefruit juice. If possible, avoid use with medications such as diltiazem, clarithromycin, boceprevir, cobicistat, conivaptan, danoprevir and ritonavir, elvitegravir and ritonavir, idelalisib, indinavir and ritonavir, itraconazole, ketoconazole, lopinavirand ritonavir, nefazodone, nelfinavir, paritaprevir and ritonavir and (ombitasvir and/or dasabuvir), posaconazole, ritonavir, saquinavir and ritonavir, tipranavir and ritonavir, troleandomycin, and voriconazole.