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Buy Rydapt Online

A prescription is required for this item.
No generic alternative is available at this time.
BRAND LISTING - Rydapt (Midostaurin)
Dosage Pack Size & Price Qty
25mg
Product description medically reviewed by Dr. Ami Patel, PharmD (Jan 30, 2020)

What is Rydapt?

Rydapt, also known as midostaurin, is a prescription medicine that is used in combination with chemotherapy to treat certain types of cancers and blood disorders. It is a kinase inhibitor that works by disrupting the activity of several proteins called kinases that influence cancer cells and blood cells. In particular, the drug influences the activity of the FLT3 gene that facilitates the production of fms-like tyrosine kinase 3 (FLT3) FLT3, which is a protein that regulates cell growth, division, and survival.

Conditions treated by Rydapt

Rydapt is administered in conjunction with certain chemotherapy medicines for the treatment of newly diagnosed acute myeloid leukemia (AML) in adults who have a FLT3 gene mutation. A clinician will conduct a test to make sure an individual is FLT3 mutation-positive, to determine candidacy for this treatment. It is not recommended for use as a standalone treatment approach to promote remission in individuals diagnosed with AML.

Rydapt is also prescribed to treat the following blood disorders in adults: mast cell leukemia (MCL), aggressive systemic mastocytosis (ASM), or systemic mastocytosis with associated hematological neoplasm (SM-AHN).

The safety and efficacy of prescribing Rydapt to children is currently unknown.

What to know before using Rydapt

The following factors should be considered before taking Rydapt (Midostaurin).

Tell your doctor if you are allergic to any of the ingredients or if you have any other known allergies. This medication contains inactive ingredients that may cause allergic reactions or side effects. If you are hypersensitive to midostaurin or its excipients, you cannot take Rydapt. Hypersensitivity reactions include: flushing, chest pain, anaphylactic shock, shortness of breath (dyspnea), and severe swelling beneath the skin (angioedema).

Speak with your pharmacist about possible reactions.

Before using this medication, tell your doctor or pharmacist your medical history, especially with regard to breathing and lung problems.

In addition, tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Do not open or crush capsules.

Rydapt cannot be taken during pregnancy as it may harm an unborn baby. It can also pass into breastmilk. Therefore, mothers who are nursing should not take this medication. Accordingly, breastfeeding should be discontinued during treatment and should not be resumed for at least 4 months following the last dose.

If you become pregnant while taking this medication or think you may be pregnant, speak with your doctor right away. If you are able to become pregnant, your doctor should conduct a pregnancy test 7 days before you start taking Rydapt.

Effective birth control should be used during treatment and for at least 4 months following the last dose.

Men taking Rydapt who have a female partner who may become pregnant should also use effective birth control during treatment with RYDAPT and for at least 4 months following the last dose.

Rydapt may impair fertility in both males and females. This issue should be discussed with your doctor before starting the treatment.

If you vomit after taking a dose of Rydapt, do not take another dose of Rydapt. Take your next dose at your regular scheduled time.

If you miss a dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose.

Rydapt should not be co-administered with strong CYP3A4 inducers. More specifically, it should not be taken with Carbamazepine, enzalutamide, mitotane, phenytoin, rifampin, or St. John's wort, among others.

Rydapt should not be co-administered with strong CYP3A inhibitors. Do not use with grapefruit juice. If possible, avoid use with medications such as diltiazem, clarithromycin, boceprevir, cobicistat, conivaptan, danoprevir and ritonavir, elvitegravir and ritonavir, idelalisib, indinavir and ritonavir, itraconazole, ketoconazole, lopinavirand ritonavir, nefazodone, nelfinavir, paritaprevir and ritonavir and (ombitasvir and/or dasabuvir), posaconazole, ritonavir, saquinavir and ritonavir, tipranavir and ritonavir, troleandomycin, and voriconazole.

Possible Side Effects of Rydapt

The most common side effects that have been reported for adults with acute myeloid leukemia (AML) during treatment include, but are not limited to:

  • Nausea
  • Headache
  • Vomiting
  • Bruising
  • Nose bleeds
  • Bone or muscle pain
  • Device-related infection
  • Upper respiratory infection
  • High blood sugar levels (hyperglycemia)
  • Pain, redness, or ulcers in the mouth (mucositis)
  • Low white blood cells levels along with a fever (febrile neutropenia)

The most common side effects that have been reported for adults with mast cell leukemia (MCL), aggressive systemic mastocytosis (ASM), or systemic mastocytosis with associated hematological neoplasm (SM-AHN) during treatment include, but are not limited to:

  • Fever
  • Nausea
  • Vomiting
  • Diarrhea
  • Fatigue
  • Headache
  • Constipation
  • Trouble breathing
  • Bone or muscle pain
  • Upper respiratory infection
  • Stomach or abdominal pain
  • Swelling of the hands, feet, or ankles

If side effects such as nausea, vomiting, and diarrhea worsen or do not go away during Rydapt treatment, you should contact your doctor immediately. Your doctor may prescribe medication to help prevent nausea and vomiting during treatment. Your doctor may also need to adjust the dose, temporarily stop the treatment, or completely stop the treatment.

In addition, another side effect may be lung problems that may result in death when it is used alone or in combination with other chemotherapy medicines. If any new or worsening lung symptoms such as coughing, shortness of breath, or chest discomfort develop, get medical help right away.

Rydapt FAQ's

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  • The information provided on the NorthWestPharmacy.com website is intended to facilitate awareness about healthcare products and medical conditions generally but it is not a substitute for professional medical attention or advice. You should always speak with a qualified healthcare practitioner before taking any prescription or non-prescription drug.