Tylenol Sinus Extra Strength Day + Night Combo Pack contains several medications, depending on whether you need help to relieve sinus pain and congestion during the day without feeling drowsy or if you need help relieving sinus pain and congestion while also taking advantage of a good night’s sleep, or both! For getting through the day, take the Daytime Tylenol that contains Acetaminophen for pain relief, and Phenylephrine, a nasal decongestant. For more help so you can get some rest, the Nighttime Tylenol contains Acetaminophen, Phenylephrine, and antihistamine called Chlorpheniramine Maleate that will cause drowsiness. Tylenol Sinus Extra Strength Day + Night Combo Pack has you covered day and night.