TOLL-FREE PHONE: 1-866-539-5330
TOLL-FREE FAX: 1-866-539-5331

Buy Vagifem Online

A prescription is required for this item.
No generic alternative is available at this time.
BRAND LISTING - Vagifem (Estradiol)
Dosage Pack Size & Price Qty
10mcg (CA)


What Is Vagifem Used For?

Vagifem is a local vaginal hormone replacement therapy medication used to treat menopausal changes in and around the vagina. It comes in a tablet containing Estradiol, which restores the levels of estrogen in the vagina.

During and after menopause, many women experience vaginal atrophy, which is when vaginal tissues get thinner and irritated more easily. Vaginal atrophy can lead to dryness, itchiness, and discomfort, which can then lead to painful intercourse. The root cause of vaginal atrophy is a decline in estrogen levels.

While over-the-counter (OTC) gels, ointments, and inserts may temporarily relieve dryness and discomfort, Vagifem can alleviate the dryness that causes these symptoms.

Once the Vagifem tablet is inserted as directed, it slowly dissolves in the vaginal tissues, releasing the estrogen directly where it is needed (very little reaches the bloodstream). Over time, vaginal tissues can thicken and become supple and moist.

Drugs Similar to Vagifem

Conditions Treated by Vagifem

In their 40s, many women start to experience irregular menstrual cycles, sleep problems, minor hot flashes, and vaginal dryness. This transition is known as perimenopause. After 12 consecutive months without a period, a woman officially reaches menopause.

If you are bothered by the hot flashes, mood changes, restless sleep, and vaginal atrophy that often accompany menopause, your physician may prescribe an oral or transdermal estrogen and progesterone. While the symptoms of menopause decrease and disappear over time, vaginal dryness, itchiness, and discomfort may remain. Vagifem is ideal for treating the symptoms of vaginal irritation and dryness directly at the affected area.

Vagifem should provide relief from vaginal atrophy after the first two weeks of use.

What to Know Before Using Vagifem

  • Do not use Vagifem if you are pregnant or may be pregnant.

  • Inform your doctor of other medical conditions or allergies you have. Tell your doctor if you are taking any OTC or Rx drugs, including herbal remedies and vitamin or dietary supplements.

  • To reduce any health risks from estrogen hormone therapy, your doctor should recommend the lowest Vagifem dose available and it should only be used short-term.

  • The risk of blood clots, heart attack, or stroke is increased if you have diabetes, hypertension, high cholesterol, or smoke while taking hormones.

  • Ask your doctor to explain how to use the plunger properly.

  • Grapefruit and grapefruit juice may interact with Vagifem.

Possible Vagifem Side Effects

As with all prescription drugs, there are potential side effects of using Vagifem.

Some people may experience:

  • Weight gain
  • Back pain
  • Headache
  • Vaginal discharge

Vagifem FAQs

Where can I get the lowest price for Vagifem?

For the lowest Vagifem cost, you can purchase Vagifem at You can buy Vagifem 10 mcg or Vagifem 25 mcg, according to your doctor’s recommendation for the right Vagifem dosage for you. No coupon is required at, where you can compare Vagifem pricing by different dosage options.

Does Vagifem cause weight gain?

Vagifem may lead to fluid retention and fluctuations in weight, but these are not common side effects.

Can Vagifem increase my risk for breast cancer?

Using estrogens with progestins may increase your risk for heart attack, stroke, breast cancer, or blood clots. Estrogens may increase the chances of getting certain types of cancer, including that of the breast or uterus.

The information provided on the website is intended to facilitate awareness about healthcare products and medical conditions generally but it is not a substitute for professional medical attention or advice. You should always speak with a qualified healthcare practitioner before taking any prescription or non-prescription drug.