Myfembree Complete Guide: Fibroids, Weight Loss, Pregnancy, & More

What Is Myfembree? A Quick Overview

Myfembree is a once-daily oral medication used to treat two common gynecological conditions: uterine fibroids and endometriosis.

It’s a relatively recent medication; it’s only been approved to treat these conditions since 2021.

But, for women who are premenopausal and wish to treat heavy bleeding and pain without surgery, increasingly, it’s a popular and reliable option.

Myfembree is unique among endo and fibroids medications because it combines three active ingredients.

They are:

Packaging relugolix (which you can think of as a switch that helps modulate hormone production) with specific, relevant hormones (estrogen and progestin) provides patients with an effective yet gentle way to manage pain.

Together, these three ingredients reduce hormone levels that could be leading to unhelpful symptoms, while also balancing those effects to minimize common side effects of hormone suppression.

Unfortunately, Myembree isn’t a cure for endo or fibroids.

That said, taking it regularly, as approved by your doctor, can significantly improve a patient’s quality of life by reducing pain and bleeding.

How Does Myfembree Work? Usage and Mechanism of Action Explained

Here’s the short answer:

Patients take Myfembree daily, as an oral tablet, with or without food. After taking it regularly for a few months, most patients notice symptom relief.

Wondering how that happens?

Here’s a bit of a deeper dive:

Myfembree’s Mechanism of Action—How It Provides Relief

The ingredient providing most of the pain-busting action in Myfembree is relugolix.

Taking relugolix can help block instructions coming from the brain that tell other parts of the body, like the ovaries, to make hormones like progesterone and estrogen.

These hormones are extremely important for a person’s overall health, and particularly in the normal function of the menstrual cycle, but when the human body makes too much of these hormones, problems can happen.

By reducing those hormone levels, Myfembree can:

But here’s the twist: fully suppressing estrogen can lead to unwanted side effects, like hot flashes or bone loss.

That’s why Myfembree also includes “add-back therapy” – or low doses of estrogen and progestin – to help maintain hormonal balance.

Think of it like a dimmer switch for your hormones: Myfembree turns them down, not off entirely.

How Long Does It Take Myfembree to Work?

After you start taking Myfembree, how long do you have to take it before you can reasonably expect something to start happening?

This depends entirely on the specific way that your unique body is dealing with the influx of overproduced hormones fueling your endo or fibroids, but, that said, there is a general time when you can start asking questions.

Many patients begin to see improvement in symptoms – especially bleeding – within the first 4 to 8 weeks. You may need to wait up to 3 months for the full benefit of Myfembree to kick in.

Once you’ve reached that length of time taking Myfembree, if you’re not satisfied with your experience, talk to your healthcare team.

They may be able to help you learn more about what’s going on and, if necessary, recommend any helpful updates to your treatment regimen.

What Is Myfembree Used For? Approved and Off-Label Uses

Myfembree has been approved for the treatment of fibroids and endometriosis. Since it’s a newer medication, there haven’t been as many off-label uses found for it (yet) but talk to your doctor to learn more about any other ways that Myfembree can help people thrive.

In the meantime, here’s how Myfembree can assist with the treatment of its two approved indications.

How Does Myfembree Treat Uterine Fibroids?

First things first: What are uterine fibroids?

Uterine fibroids are noncancerous growths that often cause heavy, prolonged periods, pelvic pain, and bloating.

They’re scary but usually not life-threatening. They’re painful, and they’re very common.

If you have one, you’re far from alone.

Myfembree was developed to help premenopausal women get relief from the pain associated with uterine fibroids.

Having too much progesterone and estrogen in your body can feed fibroid growth. Myfembree targets the root of the problem by:

If treating fibroids without surgery is a goal of yours, Myfembree may be at least worth looking into.

How Does Myfembree Treat Endometriosis?

Myfembree is also approved to treat moderate to severe endometriosis-related pain. Endometriosis can present in a few ways and come with a wide array of symptoms, but some of the more common include:

Since Myfembree reduces estrogen but does so gently, it can help slow the growth of endometrial tissue located outside of the uterus (so, tissue growing where it’s not supposed to be) without triggering low-hormone symptoms.

That misplaced tissue is usually what causes the bulk of endometriosis pain, so, without that tissue, patients tend to experience significant relief.

Most people get to that stage after taking Myfembree for a few months.

Myfembree and Your Period: What to Expect

If you’re aware of what estrogen and progesterone do in your body, you might be nodding along – but also wondering what taking a medication that suppresses those hormones might do to your body.

After all, perhaps having excess estrogen and progesterone in your system might cause fibroids or endometrial tissue growing outside the uterus – but estrogen and progesterone are also helpful for menstrual cycling, mood stability, and even things like sleep regulation and bone health.

Let’s take a quick peek at what Myfembree does aside from treating your fibroids or endo.

Does Myfembree Stop Your Period?

For many users, yes. Myfembree is designed to significantly reduce or eliminate menstrual bleeding in people with fibroids or endometriosis.

Some people stop getting periods altogether after one to two months.

Others may experience light or irregular bleeding.

Know this upfront: While changes to your cycle may happen, lack of a period is not usually a cause for concern while patients are on Myfembree.

That said, if your bleeding is unusually heavy or painful after starting treatment, contact your doctor. That could signal that your dosage needs adjustment or that another issue is present.

Does Myfembree Cause Bleeding?

This might sound odd after the last question, but, yes, Myfembree can also cause bleeding.

When patients start taking Myfembree, it’s relatively common for them to experience occasional breakthrough bleeding or spotting. This should go away after the first few months.

Does Myfembree Stop Ovulation?

Yes. Ovulation is typically suppressed while taking Myfembree. This is part of how it reduces symptoms related to fibroids and endometriosis. This is also why Myfembree stops your period: Ovulation triggers the second half of the menstrual cycle, so, without ovulation, no period.

If Myfembree is starting to sound intriguing because of its ovulation-suppressing qualities, it’s a good idea to note that Myfembree is not formally approved as a contraceptive.

While Myfembree does stop ovulation, it may not do so consistently enough to be a reliable form of pregnancy prevention.

Myfembree and Weight: Loss, Gain, or Neither?

Hormonal medications often come with concerns about weight changes.

Those concerns may be justified, but it’s important to know the facts.

That way, you and your healthcare team can make data-based decisions to support your health goals as effectively as possible.

Does Myfembree Cause Weight Gain?

Myfembree can cause weight gain, but it’s not a common side effect.

Managing and manipulating your hormones can always result in some mild increases or even decreases in weight as your body adjusts to its new normal.

Most Myfembree users who talk about weight changes note that they’re experiencing symptoms that track with hormonal fluctuations, like fluid retention (or bloating), increased appetite, or changes in their physical activity due to reduced symptoms.

All of those can impact weight loss or gain, too.

So while Myfembree doesn’t generally cause weight gain directly, your experience with the medication and any indirect effects it may cause could result in weight changes.

If you notice a weight change trend that you feel requires attention, talk to your doctor. They may be able to help you with resources, recommendations, or any required shifts in your medication strategy.

What Happens When You Stop Taking Myfembree?

Once you start taking Myfembree, the idea is that you’d take it for about two years and then stop and at least reassess. This is just a precautionary measure most physicians recommend to avoid any symptoms associated with long-term hormone reduction, like bone loss.

However, that tidy two-year time limit may not always be possible, or even preferable.

If you’re planning to get pregnant, for example, or if you just decide that Myfembree isn’t for you, you’re going to need an exit strategy.

Here’s a quick overview of what happens when you stop taking Myfembree:

As always, your mileage may vary. The one very important thing to note is that it’s never a good idea to stop Myfembree without talking to your doctor first.

Even if you’re experiencing unwanted symptoms and know it’s time to explore other options, don’t just toss your meds and quit suddenly – that could make your symptoms worse!

Is Myfembree Safe? Side Effects and Risks to Know

Most users tolerate Myfembree well, but like all prescription medications, it comes with potential side effects.

Understanding what’s common—and what’s not—can help you know what to expect and when to call your provider.

Here’s what you need to know.

Common Myfembree Side Effects

The side effects most people experience with Myfembree are generally mild and temporary. As your body gets used to the drug, they should go away.

These side effects include:

There is a short list of less common but more serious side effects that you should know about but try not to worry about.

In some cases, taking Myfembree, especially long-term, can lead to reactions like bone mineral density loss, increased LDL cholesterol, elevated liver enzymes, and risk of blood clots.

To keep you safe, your healthcare team may ask you to get regular blood tests to monitor the way your body’s responding to Myfembree. This can put more on your to-do list and feel like a lot to juggle, but just remember: Information, especially about your body, is power!

How Much Does Myfembree Cost? +Where to Buy

If you’re paying for Myfembree in the United States, you could be paying a lot (a lot) of money. A 28-day supply of the medication can cost as much as $1,200.00.

But, here’s the thing: If you’re looking for an alternative, you’re in luck. Here, through NorthWestPharmacy.com, you can buy a 28-day supply of Myfembree for about $210.00 – savings of up to 82%.

For those managing heavy bleeding from fibroids or chronic pelvic pain from endometriosis, Myfembree can offer real relief … and it can do so without necessary surgery or monthly injections. If you’re ready to try Myfembree, the team at NorthWestPharmacy.com is ready to assist.

Check out our Myfembree information page to learn more about affordable pricing, discreet delivery, and the other ways our team can support you.