Zoryve Cream Questions Answered: Side Effects, Generic, & More

What Is Zoryve Cream?

Zoryve is a prescription cream that contains roflumilast, a PDE4 inhibitor.

“PDE4” is an acronym that stands for “phosphodiesterase-4”.

That’s a complicated-sounding term for a type of medicine that helps calm inflammation in the skin – without using corticosteroids.

This is helpful because many of the trickiest and common skin conditions people face can be traced back to inflammation.

As Dr. Brynna Connor, M.D., a board-certified family medicine physician who specializes in regenerative medicine, says:

“Inflammatory skin conditions typically have symptoms that come and go. Sometimes, these diseases become more active, causing symptoms to worsen. These periods are called “flares.” Other times, symptoms will go into remission – they will lessen or even disappear. One key aspect of treating eczema, seborrhea, and psoriasis is to stop flares from coming on.”

Zoryve Cream is currently approved to treat two specific skin conditions:

When a doctor prescribes Zoryve Cream to treat one of these conditions, they can weigh a couple of options in terms of drug strength to match the medication to the intended outcome.

You’ll see Zoryve Cream prescribed in one of two concentrations:

Most people who take Zoryve Cream will use it once daily, with or without moisturizer (as suits their preference), directly on the affected areas of their skin.

Does Zoryve Cream Cause Side Effects?

Zoryve Cream is a powerful prescription topical medication.

As such – and as with any other medication – there are possible side effects that you should be aware of before you start using Zoryve Cream.

Fortunately, there is good news:

Zoryve is generally well tolerated.

For the most part, you’ll just need to keep an eye out for the following commonly-reported side effects:

For most people, these symptoms will be short-lived.

By the time you’ve taken the medication for a few days, as your body gets used to the new drug, any common side effects you’re experiencing should melt away.

Still, if any side effect becomes severe or persists for more than a few days, it’s a good idea to talk with your doctor or pharmacist.

Is Zoryve Cream a Steroid?

No!

Zoryve is not a steroid.

In fact, that’s one of the things that makes it stand out from other medications like it.

Steroid creams have long been used to treat chronic skin conditions like psoriasis and eczema, but they come with baggage. Think: Long-term side effects like thinning skin, increased infection risk, and even hormonal disruption.

Zoryve offers another route.

As a non-steroidal topical cream that works by blocking PDE4, an enzyme involved in skin inflammation, Zoryve helps reduce redness, itching, and plaque formation without the drawbacks of steroid use.

How Old Do You Have to Be to Use Zoryve Cream?

Zoryve is currently approved for use in patients aged 6 years and older for both plaque psoriasis and atopic dermatitis.

Because it’s steroid-free and formulated for sensitive skin, Zoryve is often a good option for children who require long-term treatment, or who didn’t respond well to steroid creams.

Of course, all pediatric use should be directed and monitored by a licensed healthcare provider.

How Much Does Zoryve Cream Cost?

As a newer medication with a specific value add and an in-demand use case, Zoryve Cream is on the expensive side.

American patients may pay as much as $900.00 for just one tube of this topical medication!

While that one tube may last for several months with regular use, that’s still a lot of money to pay for just one med.

If you’re looking for alternate options, you’re in the right place.

Through NorthWestPharmacy.com, you can buy that same tube of brand-name Zoryve Cream for just under $400.00 – savings of around 55%.

Is There a Zoryve Cream Generic?

Not yet.

There isn’t currently a generic version of Zoryve Cream, since the patents for the brand-name cream are still active.

That simplifies things in some ways. You don’t have to figure out if Zoryve Cream or a generic works better for you, for example. While generic versions of drugs should be functionally equivalent to brand-name variants, there’s always the risk that a filler ingredient in one version of the medication could trigger an allergic reaction (or something like that).

For now, though, there’s only brand Zoryve Cream to learn more about.

That’s the plus side.

The downside, of course, is that Zoryve Cream is very expensive.

However, if you’re looking for a lower-cost alternative, you may be able to find creative ways to source your brand-name Zoryve Cream.

(Buying your Zoryve Cream through an international and online Canadian drugstore website for up to 55% savings might be a good option!)

Can Zoryve Cream Be Used for Erectile Dysfunction?

Here’s a question that’s been coming up a lot lately – and one that’s causing more confusion than necessary.

Can Zoryve cream be used to treat erectile dysfunction (ED)?

The short answer is…

…No. It cannot.

Zoryve is designed as a topical skin treatment for inflammatory conditions like plaque psoriasis and eczema. It has no known use or effect on erectile function.

So why are people searching for Zoryve in connection with ED?

It may be due to a simple mix-up between roflumilast (the active ingredient in Zoryve), which is a PDE4 inhibitor, and oral PDE5 inhibitors – which treat ED.

PDE4 inhibitors and PDE5 inhibitors may sound similar.

In fact, we’ll go ahead and validate that. They do sound similar.

But they do very different things.

Pharmaceutical jargon is unhelpful like that, sometimes.

PDE4 inhibitors and PDE5 inhibitors act on completely different enzymes in the body and are used for entirely different conditions.

If you’re looking for an ED treatment, speak with your healthcare provider about medications geared specifically to help you achieve your ED-related goals. Zoryve Cream, while extremely helpful for people dealing with atopic dermatitis or plaque psoriasis, is not going to be helpful for you!

Zoryve Cream in Canada: Is It Available?

Yes. Zoryve is available in Canada.

Its availability can vary by province, pharmacy, and insurance plan, though.

And if you’re an American seeking to buy Zoryve Cream from Canada, it can be difficult to figure out where to begin.

International and internet pharmacies for Canada drugs may be your answer. Here, through NorthWestPharmacy.com, you can access brand-name medications like Zoryve Cream at competitive prices – and enjoy other perks of online shopping, like timely shipping directly to your front door.

Zoryve Cream Alternatives: What Else Is Out There?

Zoryve Cream can be very helpful for many people. If you or a loved one is looking for a new way to manage symptoms relating to atopic dermatitis or plaque psoriasis, it may be worth a try.

That said, Zoryve Cream isn’t for everyone.

If you and your healthcare provider decide that Zoryve isn’t the right fit – maybe due to cost, availability, or side effects – you still have options. A wide range of topical treatments for plaque psoriasis and eczema is available today.

Some commonly considered alternatives include the following.

Topical Steroids

Topical steroids like betamethasone, hydrocortisone, and clobetasol are common options for patients who aren’t trying to avoid that type of active ingredient.

These medications are very effective at reducing inflammation, but they’re not generally considered ideal for long-term use because they can trigger skin thinning and other similar risks.

Vitamin D Analogs

Medications containing analogs or versions of vitamin D, like calcipotriene (Dovonex), can help slow skin cell growth and are often combined with steroid creams for a one-two punch.

Calcineurin Inhibitors

There are other medications, like tacrolimus or pimecrolimus, that help relieve symptoms of atopic dermatitis and plaque psoriasis by offering NSAID (or non-steroidal anti-inflammatory) support.

(These can be a good choice if you need to treat sensitive skin areas, like your face or groin.)

Systemic or Biologic Medications

If your psoriasis is moderate to severe, your provider may recommend a systemic drug (like Otezla or methotrexate) or a biologic (like Humira or Skyrizi).

Each option comes with its own set of pros, cons, and indications. To make the best possible decision for you and your skin, it’s worth talking to your doctor about what will work best for your symptoms, lifestyle, and medical history.

Does Zoryve Cream Have Steroids?

No, it doesn’t.

Zoryve cream does not contain steroids.

This is one of the key reasons Zoryve has generated buzz. Many patients dealing with eczema or psoriasis are, understandably, cautious about long-term steroid use. While topical corticosteroids can be very effective, they can also thin the skin, increase the risk of bruising, and sometimes cause a rebound flare once treatment stops.

Zoryve’s active ingredient, roflumilast, is a PDE4 inhibitor, not a steroid.

This makes Zoryve a great alternative for people seeking non-steroidal treatment options … especially if you’ve previously had poor results or unwanted side effects from corticosteroids.

Zoryve Cream Age Guidelines: Who Can Use It?

Zoryve Cream is approved for use in patients aged six and older.

This can, if your doctor or your child’s doctor approves it, make Zoryve Cream an option to explore for younger children and adolescents who have plaque psoriasis.

Children do have to wait until their 6th birthday to get started, though.

For children under 6, Zoryve is not currently approved, and your child’s dermatologist may recommend alternative treatments.

Always, always consult your pediatric dermatologist or healthcare provider before introducing any new treatment to a child’s routine.

Wondering Where to Buy Zoryve Cream Online?

Since Zoryve is a relatively new drug (approved for its various uses in 2022 and 2023), it can be difficult to find it in-store near you.

And, of course, if you are able to find it, there’s no guarantee that the Zoryve near you doesn’t cost much, much more than you’re able or willing to pay.

That’s where online an online pharmacy offering Canadian drugs and international medications may be able to help you out.

If you're ready to give Zoryve a try, or you're already using it and hoping to find a better price, buying your meds from Canada can save you time, money, and stress.

Here, through NorthWestPharmacy.com, you can gain access to the same brand-name medications you’d find in your local pharmacy, along with:

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Click right here to read more about Zoryve Cream and find your required, prescribed dosage, or feel free to chat with one of our experienced service reps to learn more about the simple, straightforward process of buying medications through our secure site.

Whether you're dealing with plaque psoriasis or just looking for a reliable source for your prescription refills, we’re here to support you at every step.