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12 Best Prescription NSAIDs for Inflammation (+ Discount Prices)

speciality medications

October 4, 2022
NSAIDs for Inflammation

The best NSAIDs, or non-steroidal anti-inflammatory drugs, can provide quick solutions for acute and chronic pain.

Both over-the-counter and prescription options can be effective, are widely available, and have relatively few side effects.

By slowing down or stopping your body’s production of the tiny substances that cause itching, swelling, aches, and pains, the best NSAIDs can offer you a reliable way to get relief.

NSAIDs come in many forms, ready to solve many problems. For example, there are OTC NSAIDs for headaches and sprains, and there are strong prescription NSAIDs for inflammation associated with surgery and chronic conditions.

Which NSAID is best for your inflammation?

Here, we’ll provide clear information about the twelve top-selling NSAIDs – and even discuss exactly how patients in the United States are purchasing the best NSAIDs from Canada and internationally (for less!).

What Is the Best NSAID? A Comprehensive Guide

Let’s look at twelve top-selling strong prescription NSAIDs for inflammation – and how each one works to relieve pain.

Celebrex: The Best Prescription NSAID for Stomach Lining Health

Celebrex (celecoxib) is an NSAID prescribed to patients with arthritic pain. Its active ingredient, celecoxib, is a new type of NSAID called a selective COX-2 inhibitor. Celecoxib selectively (sometimes) inhibits (stops the action of) COX-2.

COX-2 is an enzyme that helps your body make inflammation and pain-causing substances. Essentially, if you reduce COX-2, you reduce pain.

Celebrex also addresses inflammation without triggering stomach irritation and ulcers. It only works on COX-2 without affecting COX-1, a protein necessary for stomach lining health. How Much Does Celebrex Cost?

Typically, adults take Celebrex twice daily. In America, a one-month, 60-tablet supply of Celebrex can retail for $630.00 (and up) – or around $10.50 per tablet.

Here, you can buy a one-month supply of Celebrex for about $1.30 per pill, or around $77.00 (up to 87% savings).

How Much Does Celebrex Cost?

Typically, adults take Celebrex twice daily. In America, a one-month, 60-tablet supply of Celebrex can retail for $630.00 (and up) – or around $10.50 per tablet.

Here, you can buy a one-month supply of Celebrex for about $1.30 per pill, or around $77.00 (up to 87% savings).

Nevanac Eye Drops: The Best Prescription NSAID for Cataract Surgical Recovery

Nevanac Eye Drops (nepafenac) help patients reduce inflammation and swelling in their eyes following cataract surgery.

The active ingredient in Nevanac Eye Drops, nepafenac, is a prodrug – literally, a drug stored and administered in an inactive state. Once nepafenac interacts with ocular tissues, it converts into its active form and reduces inflammation.

Prodrugs provide very targeted benefits. They also help patients avoid toxic side effects associated with unintended drug exposure.

How Much Do Nevanac Eye Drops Cost?

In America, you can find a 3mL bottle of Nevanac Eye Drops for around $335.00, or about $112.00 per mL.

That amount will only last you a few weeks.

Here, you can buy 5mL bottles of Nevanac Eye Drops for about $63.00, or around $12.60 per mL – up to 89% savings.

NSAIDs for Inflammation

Indocin Suppositories: The Best Prescription NSAID for Avoiding Stomach Symptoms

Indocin Suppositories (indomethacin) are NSAIDs that treat rheumatoid arthritis, osteoarthritis, or ankylosing spondylitis.

Since Indocin Suppositories can absorb into your bloodstream directly through a patient’s rectal mucosa (instead of needing to be digested), patients who experience nausea or other GI issues often have a better experience with this type of medication.

How Much Do Indocin Suppositories Cost?

This medication is costly in the United States – and some patients need to take several suppositories per day.

In America, a 30-tablet supply of Indocin Suppositories can retail for thousands of dollars (over $10,000). This will be a problem for many people’s budgets. offers a much more affordable price for Indocin Suppositories. Here, you’ll pay approximately just $48.00 for a box of 30 tablets, or about $1.60 for each suppository.

Oruvail SR: The Best Slow-Release Prescription NSAID

Oruvail SR (ketoprofen SR) is an NSAID that releases slowly into the patient’s bloodstream over the day.

Many unwanted side effects occur due to high, sudden spikes of concentrated active ingredients hitting a patient’s bloodstream.

Oruvail SR’s slow ramp to a full NSAID dose offers rheumatoid arthritis or osteoarthritis patients a potentially-safer option.

How Much Does Oruvail SR Cost?

At about $9.00 per tablet, or $270.00 for a 30-capsule supply, Oruvail is already more affordable than other medications we’ve discussed. can offer up to 68% savings on Oruvail SR.

Here, you can buy a four-week supply of Oruvail SR for approximately $78.00, or around $2.80 per capsule.

Treximet: The Best Prescription NSAID for Fast Migraine Relief

Treximet (sumatriptan succinate/naproxen sodium) is an NSAID that helps patients who suffer from migraines. It’s a medication with two active ingredients: Naproxen, an NSAID, and sumatriptan, a serotonin agonist and popular migraine medicine.

Instead of preventing new headaches or decreasing the overall number of migraines a person might experience, Treximet works by reducing inflammation associated with an already-in-progress migraine.

Most patients will take Treximet twice within 24 hours after the onset of migraine symptoms.

How Much Does Treximet Cost?

In America, widely available generic sumatriptan succinate/naproxen sodium costs approximately $22.00 per pill.

Purchasing your migraine medication through an international online Canada pharmacy or international drugstore site can net you significant savings of up to 51%.

Here, we sell generic sumatriptan succinate/naproxen sodium for about $10.70 per pill, or ten pills for approximately $107.00.

Acuvail: The Best Prescription NSAID Eye Drops for Single-Use Administration

Acuvail (ketorolac tromethamine) is an NSAID that, much like Nevanac Eye Drops, helps patients heal after cataract surgery.

Typically, patients will only take Acuvail for about two weeks to treat any stinging or irritation in the wake of the procedure.

Conveniently, this NSAID comes in single-use vials – so you never have to worry about using too much or too little!

How Much Does Acuvail Cost?

The convenience Acuvail offers comes at a steep price. In America, you can buy a 30-pack of Acuvail vials for just under $400.00, or about $13.00 per vial.

For up to 86% savings, consider buying your Acuvail through, instead.

Here, you can buy 60 single-use vials of Acuvail for approximately $107.00, or around $1.80 per vial.

Indocin CR: A Popular Prescription NSAID for Bursitis

Indocin CR (indomethacin controlled release)’s name may sound familiar. If you scroll up a little, you’ll see we discussed Indocin Suppositories a few moments ago.

How is Indocin CR different? What does it offer you?

The most significant difference is simple: This is an oral medication. Patients hoping to avoid taking a suppository will prefer this option.

Indocin CR is also a controlled-release NSAID, or an anti-inflammatory medication that releases slowly into the patient’s bloodstream over the day.

How Much Does Indocin CR Cost?

This version of Indocin CR is not widely available as a brand-name drug.

At, we offer an extremely affordable price on generic indomethacin. You can buy indomethacin CR here for approximately $0.90 per dose.

NSAIDs for Inflammation

Mobic: A Common Prescription NSAID for Treating Juvenile Rheumatoid Arthritis

Mobic (meloxicam) is an NSAID that can help reduce the pain associated with arthritis. It works by blocking COX-1 and COX-2, enzymes that produce prostaglandins (chemicals associated with inflammation).

Unlike some medications on this list, Mobic can be safe for very young patients. Mobic is often used to treat juvenile rheumatoid arthritis in children as young as two.

How Much Does Mobic Cost?

Through, you can buy 100 capsules of Mobic starting at about $150.00.

Feldene: The Best Prescription NSAID for Arthritis Relief

Feldene (piroxicam) is an NSAID that can relieve rheumatoid arthritis and osteoarthritis, particularly when other medications haven’t worked well for a specific patient.

However, patients should be aware of its potential side effects.

These include indigestion, abdominal pain, elevated liver enzymes, and even (in some cases) blurred vision.

How Much Does Feldene Cost?

In America, patients who require Feldene have to pay nearly $15.00 per pill, or approximately $477.00 for a one-month supply.

Alternatively, you could purchase a one-month supply of Feldene through for about $33.00, or approximately $1.10 per pill (up to 90% savings).

Pennsaid: The Best Prescription NSAID for Topical Application

Pennsaid (diclofenac sodium topical solution) is meant for external application, unlike most of the medications on this list. It comes in a vial containing liquid drops that patients massage directly into their skin for timely relief.

As the active ingredient in Pennsaid absorbs into a patient’s skin, it interferes with the inflammatory process, reducing pain and swelling.

Since this drug doesn’t need to be digested before absorption, it works more quickly than some oral alternatives.

How Much Does Pennsaid Cost?

You can buy a 2-3 month supply of Pennsaid, or a 60mL bottle, starting at about $71.00 through

Relafen: A Strong Prescription NSAID for Inflammation (and Fewer GI Symptoms)

Relafen (nabumetone) is an NSAID that, like Feldene and Mobic, is often used to help arthritis patients reduce pain and stiffness in their joints.

And, like Celebrex, Relafen works only on COX-2, leaving COX-1 alone. As COX-1 function can be necessary for maintaining the stomach lining, Relafen can be an excellent choice for patients at a higher risk for ulcers and other GI symptoms.

How Much Does Relafen Cost?

We sell 60 pills of Relafen for about $63.00, or a little more than one dollar per pill.

If you’re interested in further savings and can tolerate the generic, you can buy nabumetone through in a 16-week supply (at one pill per day) for about $77.00 – approximately $0.68 per pill.

Voltaren: An NSAID Offering Long-Term Pain Relief

Voltaren (diclofenac sodium) is an NSAID that works well as a medication for people who require long-term pain relief.

As the degenerative joint diseases Voltaren treats are often chronic, this anti-inflammatory can help people manage their conditions, year after year.

Many doctors recommend that patients take Voltaren and complete physical therapy simultaneously to strengthen their joints and muscles over the long term.

How Much Does Voltaren Cost?

Finding brand-name Voltaren available in the United States can be challenging, as there’s a widely available generic.

Here, you can buy Voltaren in a three-month supply for about $99.00, or a little over one dollar per pill.

FAQs About the Best NSAIDs

What are OTC vs. Prescription NSAIDs?

Many over-the-counter NSAIDs, or drugs you can buy without a prescription, are mild. (If you’ve ever taken ibuprofen to relieve a headache, you’ve already benefited from NSAIDs.)

The strongest NSAIDs for inflammation usually require a prescription. They come at a higher cost but provide more substantial support for patients through post-surgical recovery and those with chronic conditions.

NSAIDs for Inflammation

What is the Best NSAID for Dogs?

American patients aren’t the only ones dealing with painful inflammation and high prices.

When your canine best friend requires an anti-inflammatory to enjoy a more comfortable life, you must have access to affordable prescription and OTC pet medications.

Check out’s selection of affordable pet medications, or reach out to our team to find the best NSAIDs for dogs (or your other pets!).

How Do NSAIDs Work?

NSAIDs work by reducing your body’s production of prostaglandins, or inflammatory chemicals that make your tissues itch, swell, or hurt.

This inflammatory pathway is a natural part of your body’s immune response. However, when this response is too strong, it may be time to consider an anti-inflammatory dose of NSAIDs.

How to Buy the Best NSAIDs for Inflammation

Whether you’re looking for affordable, efficient prescription painkillers or the best NSAIDs to relieve bursitis, arthritis, and post-surgical pain, you need a simple way to buy what you need. is prepared to provide exactly that.

Contact our call center where a customer service representative is available seven days a week to place your order.

If you’d like to speak with a professional about your prescription, we have licensed pharmacists on hand Monday through Friday.

Our international and online Canadian drugs team is passionate about connecting American patients with the best NSAIDs, prices, and customer experience possible.

If you’re interested in learning more about our relentless dedication to your satisfaction, check out our 425,000+ verified customer reviews.

When you're ready to order the best NSAIDs, we’re ready to assist. Call 1-866-539-5330 to learn more about what we can offer you, or place an order in just a few clicks through our safe, intuitive website.

The information provided on the website is intended to facilitate awareness about healthcare products and medical conditions generally but it is not a substitute for professional medical attention or advice. You should always speak with a qualified healthcare practitioner before taking any prescription or non-prescription drug.
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